December 8, 2022


Selection of some recent publications

Aleman, A., Lincoln, T., Bruggeman, R., Melle, I., Arends, J., Arango, C., Knegtering, R. (2017). Treatment of negative symptoms: where do we stand, and where do we go? Schizophrenia Research, 186, 55-62. doi: 10.1016/j.schres.2016.05.015

Bracht T, Horn H, Strik W, Federspiel A, Razavi N, Stegmayer K, Wiest R, Dierks T, Müller TJ, Walther S. White matter pathway organization of the reward system is related to positive and negative symptoms in schizophrenia. Schizophr Res. 2014 Mar;153(1-3):136-42. doi:

Butcher, I., Berry, K., & Haddock, G. (2020). Understanding individuals’ subjective experiences of negative symptoms of schizophrenia: A qualitative study. The British Journal of Clinical Psychology, 10.1111/bjc.12248.

Chaix J, Golay P, Fankhauser C, Nguyen A, Gooding DC, Favrod J. Confirmatory Factor Analysis of the French Version of the Anticipatory and Consummatory Interpersonal Pleasure Scale. Front Psychol. 2017 Jul 28;8:1296. doi: 10.3389/fpsyg.2017.01296. 

Deserno L, Huys QJ, Boehme R, Buchert R, Heinze HJ, Grace AA, Dolan RJ, Heinz A, Schlagenhauf F. Ventral striatal dopamine reflects behavioral and neural signatures of model-based control during sequential decision making. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1595-600. doi:

Dollfus S, Lyne J. Negative symptoms: History of the concept and their position in diagnosis of schizophrenia. Schizophr Res. 2016 Jul 8. pii: S0920-9964(16)30291-2. doi:

Engel, M. & Lincoln, T. M. (2017). Concordance of self- and observer-rated motivation and pleasure in patients with negative symptoms and healthy controls. Psychiatry Research, 247, 1-5. doi: 10.1016/j.psychres.2016.11.013

Favrod J, Nguyen A, Chaix J, Pellet J, Frobert L, Fankhauser C, Ismailaj A, Brana A, Tamic G, Suter C, Rexhaj S, Golay P, Bonsack C. Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial. Psychother Psychosom. 2019;88(2):84-95. doi: 10.1159/000496479. 

Favrod J, Nguyen A, Tronche AM, Blanc O, Dubreucq J, Chereau-Boudet I, Capdevielle D, Llorca PM. Impact of Positive Emotion Regulation Training on Negative Symptoms and Social Functioning in Schizophrenia: A Field Test. Front Psychiatry. 2019 Jul 26;10:532. doi: 10.3389/fpsyt.2019.00532. 

Favrod J, Nguyen A, Fankhauser C, Ismailaj A, Hasler JD, Ringuet A, Rexhaj S, Bonsack C. Positive Emotions Program for Schizophrenia (PEPS): a pilot intervention to reduce anhedonia and apathy. BMC Psychiatry. 2015 Sep 29;15:231. doi: 10.1186/s12888-015-0610-y.

Galderisi, Faerden, Kaiser. Dissecting negative symptoms of schizophrenia: History, assessment, pathophysiological mechanisms and treatment. Schizophr Res. 2016 May 13. pii: S0920-9964(16)30195-5. doi:

Galderisi S, Merlotti E, Mucci A. Neurobiological background of negative symptoms. Eur Arch Psychiatry Clin Neurosci. 2015 Mar 24.

Golay P, Thonon B, Nguyen A, Fankhauser C, Favrod J. Confirmatory Factor Analysis of the French Version of the Savoring Beliefs Inventory. Front Psychol. 2018 Feb 19;9:181. doi: 10.3389/fpsyg.2018.00181.

Hartmann MN, Hager OM, Reimann AV, Chumbley JR, Kirschner M, Seifritz E, Tobler PN, Kaiser S. Apathy but not diminished expression in schizophrenia is associated with discounting of monetary rewards by physical effort. Schizophr Bull. 2015 Mar;41(2):503-12. doi:

Hartmann-Riemer, M., Kirschner, M., Kaiser, S. 2018. Effort-based decision-making paradigms as objective measures of apathy in schizophrenia? Curr Opin Behav Science. doi: 10.1016/j.cobeha.2018.01.009 

Kaiser S, Lyne J, Agartz I, Clarke M, Mørch-Johnsen L, Faerden A. Individual negative symptoms and domains – Relevance for assessment, pathomechanisms and treatment. Schizophr Res. 2016 Jul 21. pii: S0920-9964(16)30329-2. doi: 10.1016/j.schres.2016.07.013

Kirschner M, Aleman A, Kaiser S. Secondary negative symptoms – A review of mechanisms, assessment and treatment. Schizophr Res. 2016 May 23. pii: S0920-9964(16)30224-9. doi:

Kirschner, M.,* Cathomas, F., * Manoliu, A., Habermeyer, B., Simon, J., Seifritz, E., Tobler, PN, Kaiser, S., 2019. Shared and dissociable features of apathy and reward system dysfunction in bipolar disorder and schizophrenia. Psychological Medicine. (accepted) *equal contribution

Kirschner, M., Haugg, A., Manoliu, A., Simon, J.J., Huys, Q.J.M., Seifritz, E., Tobler, P.N., Kaiser, S., 2018a. Deficits in context-dependent adaptive coding in early psychosis and healthy individuals with schizotypal personality traits. Brain J. Neurol. 141, 2806�2819. 

Kluge, A.*, Kirschner, M.*, Hager, OM., Bischof M., Habermeyer B., Seifritz E., Walther S., Kaiser S. 2017. Combining actigraphy, ecological momentary assessment and neuroimaging to study apathy in patients with schizophrenia. Schizophr Res. doi:10.1016/j.schres.2017.09.034. *equal contribution 

Liemburg E, Castelein S, Stewart R, van der Gaag M, Aleman A, Knegtering H; Genetic Risk and Outcome of Psychosis (GROUP) Investigators. Two subdomains of negative symptoms in psychotic disorders: established and confirmed in two large cohorts. J Psychiatr Res. 2013 Jun;47(6):718-25.

Liemburg EJ, Dlabac-De Lange JJ, Bais L, Knegtering H, van Osch MJ, Renken RJ, Aleman A. Neural correlates of planning performance in patients with schizophrenia–relationship with apathy. Schizophr Res. 2015 Feb;161(2-3):367-75.

Lincoln, T.M, Dolfus, S. & Lyne, J. (2017). Current developments and challenges in assessment of negative symptoms. Schizophrenia Research, 186, 8-18. doi: 10.1016/j.schres.2016.02.035. .

Lincoln, T.M., Riehle, M., Pillny, M., Helbig-Lang, S., Fladung, A.-K., Hartmann-Riemer, M., Kaiser, S. (2017). Using functional analysis as a framework to guide individualized treatment for negative symptoms. Frontiers in Psychology. 8:2108. doi: 10.3389/fpsyg.2017.02108. .

Lüllmann E, Lincoln TM. The Effect of an Educating versus Normalizing Approach on Treatment Motivation in Patients Presenting with Delusions: An Experimental Investigation with Analogue Patients. Schizophr Res Treatment. 2013;2013:261587.

Mucci A, Dima D, Soricelli A, Volpe U, Bucci P, Frangou S, Prinster A, Salvatore M, Galderisi S, Maj M. Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback. Psychol Med. 2015 Jun;45(8):1765-78.

Mucci A, Merlotti E, ��ok A, Aleman A, Galderisi S. Primary and persistent negative symptoms: Concepts, assessments and neurobiological bases. Schizophr Res. 2016 May 27. pii: S0920-9964(16)30238-9.

Mørch-Johnsen L, Nesvåg R, Faerden A, Haukvik UK, Jørgensen KN, Lange EH, Andreassen OA, Melle I, Agartz I. Brain structure abnormalities in first-episode psychosis patients with persistent apathy. Schizophr Res. 2015 May;164(1-3):59-64.

Nguyen A, Frobert L, McCluskey I, Golay P, Bonsack C, Favrod J. Development of the Positive Emotions Program for Schizophrenia: An Intervention to Improve Pleasure and Motivation in Schizophrenia. Front Psychiatry. 2016 Feb 17;7:13. doi: 10.3389/fpsyt.2016.00013.

Riehle, M., Böhl, M. C., Pillny, M., & Lincoln, T. M. (2020). Efficacy of psychological treatments for patients with schizophrenia and relevant negative symptoms: A meta-analysis. Clinical Psychology in Europe, 2(3).

Riehle, M., Mehl, S., & Lincoln, T.M. (2018). The specific costs of expressive negative symptoms in schizophrenia: Reduced smiling predicts interactional outcome. Acta Psychiatrica Scandinavica, 138(2), 133-144. doi: 10.1111/acps.12892.

Riehle, M. & Lincoln, T.M. (2017). Social consequences of subclinical negative symptoms: An EMG study of facial expression within a social interaction. Behavior Therapy and Experimental Psychiatry, 55, 90-98. .

Riehle, M, Pillny, M., & Lincoln, T.M. (2017). Ist Negativsymptomatik bei Schizophrenie �berhaupt behandelbar? Ein systematisches Literatur-Review zur Wirksamkeit psychotherapeutischer Interventionen f�r Negativsymptomatik. Verhaltenstherapie, 27(3), 199-208. doi: 10.1159/000478534. .

Schlier, B., Engel, M., Fladung, A.-K., Fritzsche, A., Lincoln, T. M. (2017). The relevance of goal-orientation for motivation in high versus low proneness to negative symptoms. Journal of Behavior Therapy and Experimental Psychiatry. 55, 113-120. doi: 10.1016/j.jbtep.2017.01.004. .

Schneider, K., Michels, L., Hartmann-Riemer, M.N., Burrer, A., Tobler, P.N., St�mpfli, P., Kirschner, M., Seifritz, E., Kaiser, S., 2018. Cerebral blood flow in striatal regions is associated with apathy in patients with schizophrenia. J. Psychiatry Neurosci. JPN 43, 170150. 

Stepien M, Manoliu A, Kubli R, Schneider K, Tobler PN, Seifritz E, Herdener M, Kaiser S, Kirschner M. Investigating the association of ventral and dorsal striatal dysfunction during reward anticipation with negative symptoms in patients with schizophrenia and healthy individuals. PLoS One. 2018 Jun 18;13(6):e0198215. doi: 10.1371/journal.pone.0198215. eCollection 2018. 

Walther S, Stegmayer K, Horn H, Rampa L, Razavi N, Müller TJ, Strik W. The Longitudinal Course of Gross Motor Activity in Schizophrenia – Within and between Episodes. Front Psychiatry. 2015 Feb 5;6:10. eCollection 2015.

Older papers

Deserno L, Huys QJ, Boehme R, Buchert R, Heinze HJ, Grace AA, Dolan RJ, Heinz A, Schlagenhauf F. Ventral striatal dopamine reflects behavioral and neural signatures of model-based control during sequential decision making. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1595-600.

Deserno L, Sterzer P, Wüstenberg T, Heinz A, Schlagenhauf F. Reduced prefrontal-parietal effective connectivity and working memory deficits in schizophrenia. J Neurosci. 2012 Jan 4;32(1):12-20.

Hager, O.M., Kirschner, M., Bischof, M., Hartmann-Riemer, M.N., Kluge, A., Seifritz, E., Tobler, P.N., Kaiser, S., 2015. Reward-dependent modulation of working memory is associated with negative symptoms in schizophrenia. Schizophr. Res. 168, 238�244. doi:10.1016/j.schres.2015.08.024. 

Heinz A. Dopaminergic dysfunction in alcoholism and schizophrenia–psychopathological and behavioral correlates. Eur Psychiatry. 2002 Mar;17(1):9-16.

Heinz A, Schlagenhauf F. Dopaminergic dysfunction in schizophrenia: salience attribution revisited. Schizophr Bull. 2010 May;36(3):472-85. Juckel G, Schlagenhauf F, Koslowski M, Wüstenberg T, Villringer A, Knutson B, Wrase J, Heinz A. Dysfunction of ventral striatal reward prediction in schizophrenia. Neuroimage. 2006 Jan 15;29(2):409-16. Epub 2005 Sep 1.

Kirschner, M., Hager, O.M., Bischof, M., Hartmann, M.N., Kluge, A., Seifritz, E., Tobler, P.N., Kaiser, S., 2015. Ventral striatal hypoactivation is associated with apathy but not diminished expression in patients with schizophrenia. J. Psychiatry Neurosci. JPN 40, 140383. 

Kirschner, M., Hager, O.M., Muff, L., Bischof, M., Hartmann-Riemer, M.N., Kluge, A., Habermeyer, B., Seifritz, E., Tobler, P.N., Kaiser, S., 2016. Ventral Striatal Dysfunction and Symptom Expression in Individuals With Schizotypal Personality Traits and Early Psychosis. Schizophr. Bull. doi:10.1093/schbul/sbw142. 

Schlagenhauf F, Huys QJ, Deserno L, Rapp MA, Beck A, Heinze HJ, Dolan R, Heinz A. Striatal dysfunction during reversal learning in unmedicated schizophrenia patients. Neuroimage. 2014 Apr 1;89:171-80.

Schlagenhauf F, Sterzer P, Schmack K, Ballmaier M, Rapp M, Wrase J, Juckel G, Gallinat J, Heinz A. Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusions. Biol Psychiatry. 2009 Jun 15;65(12):1032-9.